25583871935
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Ran 08 May 2026 11:11PM UTC

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Build # 25583871935

Build Type

push

github

Committed by

iskandr

Commit Message

Bump version to 4.18.0

New since 4.17.0:

- #356 (#302): drop runtime PyVCF3 dep — `from varcode import load_vcf`
  no longer drags rpy2/R into sys.modules. In-tree VCFHeader parser.
- #357 (#264): SV load path end-to-end — `parse_structural_variants=True`
  now produces typed StructuralVariantEffect from `load_vcf` →
  `vc.effects()`. Sample info preserved on SV rows; INSSEQ/SVINSSEQ
  routed to `alt_assembly`; <CN0>/<CN3> distinguishable via
  `info["copy_number"]`; SV dispatch added to `Variant.effect_on_transcript`.
- #358 (#259): RNAEvidenceResolver protocol + apply hook for refining
  DNA-predicted outcomes with RNA-observed isoform evidence. New
  exports: RNAEvidenceResolver, NullRNAEvidenceResolver,
  apply_rna_evidence_to_effects, make_rna_outcome. New `rna_resolver=`
  kwarg on Variant.effects / VariantCollection.effects.
- #359 (#268 slice 1): GermlineContext input contract for germline-aware
  annotation. New exports: GermlineContext, Completeness,
  GenomeBuildMismatchError. Effect-side wiring lands in subsequent
  PRs on the #268 umbrella.

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