24735206856
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Ran 21 Apr 2026 04:58PM UTC

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Build # 24735206856

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github

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web-flow

Commit Message

Extend variant-level ranking with tiebreak tuple (closes #151) (#234)

`ranked_vaccine_peptides` previously sorted only on the top vaccine
peptide's ``combined_score``. Ties (common when either expression or
epitope score is zero) collapsed to Python-stable insertion order,
which made report ordering implementation-dependent.

Switch the sort key to ``(combined_score, n_alt_reads,
mutant_epitope_score)`` — the tuple requested on #151. When scores
tie, RNA support wins; when both tie, MHC binding score wins;
when all three tie, dict insertion order still applies (stable sort).

New tests/test_variant_ranking.py covers each tier of the tiebreak
plus the empty-peptide-list sentinel and the fully-tied case.

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