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Ran 18 Apr 2026 02:02PM UTC

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Build # 24606218622

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github

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web-flow

Commit Message

Fix #318: pass through fast's UTR/Intronic classification in protein_diff (#324)

``ProteinDiffEffectAnnotator`` was collapsing 3'UTR, 5'UTR, and deep
intronic SNVs into ``Silent`` because the whole-protein diff showed no
change. Fast's position-based classification is authoritative here —
"outside the CDS" carries location semantics a protein diff can't see.

Add a pass-through guard in ``annotate_on_transcript`` that returns
``fast_effect`` unchanged when it's ``ThreePrimeUTR``, ``FivePrimeUTR``,
or ``Intronic``. This mirrors the existing splice pass-through pattern.

Flip the two pinned divergence tests in
``tests/test_annotator_divergence_scenarios.py`` to agreement tests
(parametrized over ``dual_annotator``) covering both forward-strand
(CFTR) and reverse-strand (BRCA1) 3'UTR variants.

Closes #318. Bump version to 4.0.2.

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