24472675742
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master: 88%

Ran 15 Apr 2026 07:04PM UTC

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Build # 24472675742

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push

github

Committed by

web-flow

Commit Message

Bump varcode floor to 2.6.0 and topiary floor to 5.6.0 (#228)

Both dependencies shipped major feature waves in the past 3 days.

varcode 2.1.0 -> 2.6.0 (breaking 2.0.0 bug fixes already shipped):
- StopLoss via 3'UTR readthrough now correctly classified (#250)
- Insertion producing identical protein correctly Silent (#201)
- Sequence-aware intronic splice classification (#262)
- EffectCollection sorted by priority by default
- MutantTranscript data model + pluggable EffectAnnotator (#271 series)

topiary 5.1.0 -> 5.6.0:
- ProteinFragment / predict_from_fragments unification
- CachedPredictor with predictions-as-data, sharding, NetMHC loaders
- SelfProteome architecture for cross-reactivity analysis (preview)

No vaxrank code changes needed — full test suite (244 tests) passes
unchanged on the bumped floors. Further feature adoption tracked in #227.

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