24312524001
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Ran 12 Apr 2026 05:46PM UTC

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Build # 24312524001

Build Type

push

github

Committed by

iskandr

Commit Message

Bump version to 2.0.0

Major release: several backward-incompatible fixes landed in PRs #263
and #265.

Breaking changes:

* Silent.short_description now returns HGVS "p.{ref}{pos}=" (e.g.
  "p.R6=") instead of the literal "silent" (#217).
* Silent.aa_pos no longer includes the shared-prefix offset; it now
  points at the actual synonymous codon (#208). Callers that
  compensated for the off-by-one need to stop doing so.
* PrematureStop.short_description returns "p.{pos}ins{alt}*" when
  aa_ref is empty instead of the ambiguous "p.{pos}{alt}*" (#216).
* EffectCollection is now sorted by effect priority (most severe first)
  by default. Pass sort_key=False to disable sorting or a custom
  callable to override (#227).
* Sequence-aware splice site classification (#262): variants at +1/+2
  or -1/-2 with a non-canonical reference base are now classified as
  IntronicSpliceSite rather than SpliceDonor/SpliceAcceptor.

Other user-visible changes:

* VCF loader now skips symbolic alleles (<DEL>, <CN0>, etc.) and
  breakend notation with a warnings.warn call instead of crashing
  (#88, tracked for full support in #264).
* SNV in the stop codon with a stop-prefixed 3' UTR is now correctly
  classified as StopLoss instead of Insertion (#250, #205).
* Insertion before the stop codon that produces an identical protein
  is now correctly classified as Silent (#201).

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